Across TCGA pan-cancer cohorts, PLEKHG7 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PLEKHG7 data layer compared with 1 for mutation status.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PLEKHG7 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PLEKHG7 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.
HNSC, UCEC, and BLCA are the cancer types where PLEKHG7 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.