PLEKHG6

Across TCGA patient cohorts, PLEKHG6 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,446 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLEKHG6-associated proteins across cancer lineages are WDR7, PLEKHG6_S645, and MLF2. Each is linked with PLEKHG6 in more than 4 cancer types. Because this analysis shows association rather than direction, both PLEKHG6-to-partner and partner-to-PLEKHG6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHG6 versus WDR7 in GBM, with a Pearson correlation of -0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG6→partner) and Y-score (partner→PLEKHG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WDR7 →	-0.315	-0.493	.001	.001	3	5
HNSC	PLEKHG6_S645 →	+1.236	+1.577	<.001	<.001	3	5
LSCC	MLF2 →	+0.550	+1.088	<.001	<.001	3	5
HNSC	RFTN1 →	-0.310	-0.734	<.001	<.001	3	4
HNSC	SGPP1_S112 →	-0.441	-0.963	<.001	<.001	3	4
GBM	SYNJ1 →	-0.365	-0.400	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,446 associations by consensus.

PLEKHG6 vs WDR7 — GBM

Explore this scatter interactively →