PLEKHG6

Across TCGA patient cohorts, PLEKHG6 protein abundance is significantly associated with the RNA expression of many other genes, with 1,680 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PLEKHG6-associated genes across cancer lineages are MT1G, KRT8P26, and COX6A1P3. Each is linked with PLEKHG6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHG6-to-partner and partner-to-PLEKHG6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHG6 versus MT1G in HNSC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG6→partner) and Y-score (partner→PLEKHG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MT1G →	+1.264	+0.516	.005	<.001	3	1
HNSC	KRT8P26 →	+0.397	+0.515	.004	.004	3	1
HNSC	COX6A1P3 →	-0.155	-0.484	.003	.006	3	1
HNSC	RN7SKP51 →	+0.904	+0.413	.007	.007	3	1
HNSC	MRPL45P1 →	+0.648	+0.471	<.001	<.001	3	1
HNSC	LINC01239 →	+0.792	+0.372	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,680 associations by consensus.

PLEKHG6 vs MT1G — HNSC

Explore this scatter interactively →