PLEKHG6

Across TCGA patient cohorts, PLEKHG6 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHG6-associated genes across cancer lineages are ATM, eIF4E, and MEK1. Each is linked with PLEKHG6 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHG6-to-partner and partner-to-PLEKHG6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PLEKHG6-low versus PLEKHG6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG6→partner) and Y-score (partner→PLEKHG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.610	-3.986	<.001	<.001	3	3
UCEC	eIF4E →	+0.230	+2.137	.001	.001	3	2
UCEC	MEK1 →	+0.432	+3.000	<.001	<.001	3	2
UCEC	PCNA →	+0.223	+2.087	.002	.005	3	2
UCEC	Rad50 →	-0.167	-1.514	.043	.015	3	2
UCEC	TFRC →	+0.386	+1.247	.032	.045	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ATM by PLEKHG6 expression — UCEC

Explore this box plot interactively →