PLEKHG6

Across TCGA cell cohorts, PLEKHG6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,092 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PLEKHG6-associated GO terms across cancer lineages are Phospholipid biosynthetic process, Cellular response to alcohol, and Glycerophospholipid biosynthetic process. Each is linked with PLEKHG6 in more than 12 cancer types. Because this analysis shows association rather than direction, both PLEKHG6-to-partner and partner-to-PLEKHG6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Phospholipid biosynthetic process grouped by PLEKHG6-low versus PLEKHG6-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG6→partner) and Y-score (partner→PLEKHG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Phospholipid biosynthetic process →	+0.042	+3.089	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Cellular response to alcohol →	+0.163	+2.160	.003	.002	3	13
URINARY_TRACT	Glycerophospholipid biosynthetic process →	+0.047	+2.968	<.001	<.001	3	11
URINARY_TRACT	Glycerophospholipid metabolic process →	+0.041	+3.550	<.001	<.001	3	11
BREAST	Bundle of His cell to Purkinje myocyte communication →	+0.352	+1.710	.004	<.001	3	11
OESOPHAGUS	Regulation of postsynaptic membrane neurotransmitter receptor levels →	+0.114	+2.876	.002	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,092 associations by consensus.

Phospholipid biosynthetic process by PLEKHG6 expression — URINARY_TRACT

Explore this box plot interactively →