PLEKHG6

Across TCGA cell cohorts, PLEKHG6 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHG6-associated genes across cancer lineages are C1orf146, CFHR2, and MAGEB4. Each is linked with PLEKHG6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHG6-to-partner and partner-to-PLEKHG6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf146 grouped by PLEKHG6-low versus PLEKHG6-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG6→partner) and Y-score (partner→PLEKHG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C1orf146 →	+0.038	+3.865	<.001	.001	3	2
BLOOD_Leukemia	CFHR2 →	+0.395	+5.539	<.001	.003	3	2
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	2
OVARY	ASB17 →	+0.011	+3.807	<.001	.009	3	1
OVARY	ASZ1 →	+0.072	+3.906	<.001	.002	3	1
OVARY	KLHL40 →	+0.005	+3.865	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

C1orf146 by PLEKHG6 expression — OVARY

Explore this box plot interactively →