PLEKHG6

Across TCGA cell cohorts, PLEKHG6 mutation is significantly associated with the mutation status of many other genes, with 4,530 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHG6-associated genes across cancer lineages are KIAA1549, ARHGAP45, and ATG2A. Each is linked with PLEKHG6 in more than 4 cancer types. Because this analysis shows association rather than direction, both PLEKHG6-to-partner and partner-to-PLEKHG6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIAA1549 grouped by PLEKHG6-low versus PLEKHG6-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG6→partner) and Y-score (partner→PLEKHG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KIAA1549 →	+2.760	+3.510	.003	.003	1	5
LUNG_NSCLC_LUAD	ARHGAP45 →	+5.772	+5.772	.002	.002	1	4
OVARY	ATG2A →	+3.760	+4.099	<.001	<.001	1	4
OVARY	KIF21B →	+4.930	+3.977	.001	.001	1	4
OVARY	C3 →	+3.760	+4.099	<.001	<.001	1	4
OVARY	PTPRB →	+3.345	+3.345	.007	.007	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,530 associations by consensus.

KIAA1549 by PLEKHG6 expression — OVARY

Explore this box plot interactively →