PLEKHG4B

Across TCGA pan-cancer cohorts, PLEKHG4B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PLEKHG4B data layer compared with 28 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PLEKHG4B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PLEKHG4B expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, LSCC, and HNSC are the cancer types where PLEKHG4B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	1.000	0.825	.016	14	view →
LSCC	DFS	Median	II,III,IV	0.831	1.000	.004	5	view →
HNSC	DFS	Tertile	III,IV	1.000	0.534	.036	4	view →
LUAD	OS	Median	III,IV	1.000	0.827	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PLEKHG4B–UCEC (DFS)

Open the UCEC breakdown →