Across TCGA patient cohorts, PLEKHG4 mutation is significantly associated with the RNA expression of many other genes, with 3,501 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHG4-associated genes across cancer lineages are HMGN2P24, LINC00448, and RNF216P1. Each is linked with PLEKHG4 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLEKHG4-to-partner and partner-to-PLEKHG4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG4→partner) and Y-score (partner→PLEKHG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMGN2P24 →	+0.185	+1.363	.006	.003	3	4
CESC	LINC00448 →	+0.038	+4.579	<.001	.003	3	3
UCEC	RNF216P1 →	+0.235	+1.959	.005	.008	3	3
UCEC	TCF19 →	+0.531	+2.168	.002	<.001	3	3
UCEC	CINP →	+0.344	+2.200	<.001	<.001	3	3
UCEC	PSMC3IP →	+0.534	+1.698	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,501 associations by consensus.

Exploration

PLEKHG4 survival (RNA) · tumor vs normal (RNA) · all PLEKHG4 data types