PLEKHG3

Across TCGA patient cohorts, PLEKHG3 mutation is significantly associated with the RNA expression of many other genes, with 2,919 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHG3-associated genes across cancer lineages are OSTC, ZNF232-AS1, and SDHDP3. Each is linked with PLEKHG3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHG3-to-partner and partner-to-PLEKHG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OSTC grouped by PLEKHG3-low versus PLEKHG3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG3→partner) and Y-score (partner→PLEKHG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	OSTC →	+0.704	+3.352	<.001	.005	3	3
COAD	ZNF232-AS1 →	+0.865	+3.389	<.001	.004	3	3
COAD	SDHDP3 →	+0.370	+3.514	<.001	.005	3	3
COAD	ZNF271P →	+0.547	+3.371	.001	.004	3	3
UCEC	PLTP →	-0.805	-2.192	<.001	<.001	3	3
UCEC	CMC2 →	+0.414	+2.192	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,919 associations by consensus.

OSTC by PLEKHG3 expression — COAD

Explore this box plot interactively →