PLEKHG3

Across TCGA cell cohorts, PLEKHG3 mutation is significantly associated with the mutation status of many other genes, with 4,761 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHG3-associated genes across cancer lineages are TTC22, KIF26A, and GTF3C1. Each is linked with PLEKHG3 in more than 4 cancer types. Because this analysis shows association rather than direction, both PLEKHG3-to-partner and partner-to-PLEKHG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTC22 grouped by PLEKHG3-low versus PLEKHG3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG3→partner) and Y-score (partner→PLEKHG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTC22 →	+2.906	+2.632	<.001	<.001	1	5
LARGE_INTESTINE	KIF26A →	+1.791	+2.769	<.001	<.001	1	5
LARGE_INTESTINE	GTF3C1 →	+2.152	+2.693	<.001	<.001	1	5
CNS	LAMB4 →	+3.862	+4.347	.001	.001	1	5
LARGE_INTESTINE	DNMT1 →	+2.321	+2.321	.003	.003	1	5
BLOOD_Leukemia	PPRC1 →	+1.847	+1.959	.009	.009	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,761 associations by consensus.

TTC22 by PLEKHG3 expression — LARGE_INTESTINE

Explore this box plot interactively →