PLEKHG2

Across TCGA patient cohorts, PLEKHG2 protein abundance is significantly associated with the protein abundance of many other proteins, with 18,498 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PLEKHG2-associated proteins across cancer lineages are FN1, COL3A1, and P3H3. Each is linked with PLEKHG2 in more than 7 cancer types. Because this analysis shows association rather than direction, both PLEKHG2-to-partner and partner-to-PLEKHG2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHG2 versus FN1 in LSCC, with a Pearson correlation of 0.35.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG2→partner) and Y-score (partner→PLEKHG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FN1 →	+0.667	+0.277	<.001	.001	3	7
HNSC	COL3A1 →	+0.821	+0.434	<.001	<.001	3	6
OV	P3H3 →	+0.715	+0.739	.004	.002	1	8
UCEC	ATP5F1C →	-0.297	-0.261	<.001	<.001	3	6
BRCA	COL5A2 →	+0.828	+0.695	<.001	<.001	3	6
CCRCC	LAMB1 →	+0.590	+0.505	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,498 associations by consensus.

PLEKHG2 vs FN1 — LSCC

Explore this scatter interactively →