PLEKHG2

Across TCGA patient cohorts, PLEKHG2 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHG2-associated genes across cancer lineages are 14-3-3_epsilon, Caspase-7-cleavedD198, and GAPDH. Each is linked with PLEKHG2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHG2-to-partner and partner-to-PLEKHG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_epsilon grouped by PLEKHG2-low versus PLEKHG2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG2→partner) and Y-score (partner→PLEKHG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	14-3-3_epsilon →	+0.120	+1.782	.008	.008	3	3
COAD	Caspase-7-cleavedD198 →	+1.187	+2.708	<.001	.003	3	3
UCEC	GAPDH →	+0.377	+1.678	.017	.021	3	3
COAD	EGFR_pY1068 →	-0.437	-2.446	<.001	.018	3	2
UCEC	eIF4E →	+0.180	+2.523	.003	<.001	3	2
COAD	PDCD4 →	-0.442	-2.691	.009	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

14-3-3_epsilon by PLEKHG2 expression — SKCM

Explore this box plot interactively →