PLEKHG2

Across TCGA cell cohorts, PLEKHG2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,506 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLEKHG2-associated GO terms across cancer lineages are Nucleic acid transport, RNA transport, and Establishment of RNA localization. Each is linked with PLEKHG2 in more than 15 cancer types. Because this analysis shows association rather than direction, both PLEKHG2-to-partner and partner-to-PLEKHG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleic acid transport grouped by PLEKHG2-low versus PLEKHG2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG2→partner) and Y-score (partner→PLEKHG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Nucleic acid transport →	+0.098	+1.202	<.001	<.001	3	16
BONE	RNA transport →	+0.098	+1.202	<.001	<.001	3	16
BONE	Establishment of RNA localization →	+0.095	+1.240	<.001	<.001	3	16
BONE	RNA localization →	+0.090	+1.063	<.001	<.001	3	16
BONE	Heterochromatin organization →	+0.087	+1.439	<.001	.002	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of organelle assembly →	+0.067	+1.028	<.001	.004	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,506 associations by consensus.

Nucleic acid transport by PLEKHG2 expression — BONE

Explore this box plot interactively →