PLEKHG2

Across TCGA cell cohorts, PLEKHG2 mutation is significantly associated with the RNA expression of many other genes, with 910 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLEKHG2-associated genes across cancer lineages are S100G, TMEM213, and SPEF1. Each is linked with PLEKHG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHG2-to-partner and partner-to-PLEKHG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S100G grouped by PLEKHG2-low versus PLEKHG2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG2→partner) and Y-score (partner→PLEKHG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	S100G →	+0.827	+2.688	.001	.002	3	2
SKIN	TMEM213 →	+0.047	+3.252	<.001	<.001	3	2
BLOOD_Leukemia	SPEF1 →	+0.152	+3.711	.001	<.001	3	2
BLOOD_Leukemia	SLC32A1 →	+0.463	+1.901	<.001	.008	3	2
BLOOD_Leukemia	LENG1 →	+0.335	+2.674	.002	.003	3	2
BLOOD_Leukemia	TBC1D19 →	+0.736	+3.459	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 910 associations by consensus.

S100G by PLEKHG2 expression — LARGE_INTESTINE

Explore this box plot interactively →