PLEKHG1

Across TCGA patient cohorts, PLEKHG1 mutation is significantly associated with the RNA expression of many other genes, with 5,655 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHG1-associated genes across cancer lineages are NDUFA6, RN7SKP264, and PKN2. Each is linked with PLEKHG1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLEKHG1-to-partner and partner-to-PLEKHG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFA6 grouped by PLEKHG1-low versus PLEKHG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHG1→partner) and Y-score (partner→PLEKHG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFA6 →	+0.474	+1.721	<.001	<.001	3	4
LIHC	RN7SKP264 →	+0.162	+5.033	<.001	.009	3	3
STAD	PKN2 →	+0.560	+3.286	.009	.008	3	3
UCEC	CENPU →	+0.719	+2.110	<.001	<.001	3	3
UCEC	POLR3K →	+0.425	+3.544	<.001	<.001	3	3
UCEC	RBBP4 →	+0.394	+1.555	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,655 associations by consensus.

NDUFA6 by PLEKHG1 expression — UCEC

Explore this box plot interactively →