PLEKHF1

Across TCGA patient cohorts, PLEKHF1 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,440 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PLEKHF1-associated proteins across cancer lineages are TRIM21, IFI35, and ICAM1. Each is linked with PLEKHF1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PLEKHF1-to-partner and partner-to-PLEKHF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHF1 versus TRIM21 in HNSC, with a Pearson correlation of 0.26.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHF1→partner) and Y-score (partner→PLEKHF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRIM21 →	+0.413	+0.592	.002	.005	3	7
BRCA	IFI35 →	+0.426	+1.209	<.001	<.001	3	6
BRCA	ICAM1 →	+0.675	+1.066	<.001	<.001	3	6
CCRCC	NCF2 →	+0.496	+0.631	<.001	<.001	3	6
BRCA	SERPINB9 →	+0.452	+0.788	<.001	<.001	3	5
OV	SIPA1_S839 →	+0.519	+0.969	.004	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,440 associations by consensus.

PLEKHF1 vs TRIM21 — HNSC

Explore this scatter interactively →