PLEKHF1

Across TCGA patient cohorts, PLEKHF1 mutation is significantly associated with the RNA expression of many other genes, with 879 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHF1-associated genes across cancer lineages are LINC02662, OR2T5, and RNU6-1139P. Each is linked with PLEKHF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHF1-to-partner and partner-to-PLEKHF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02662 grouped by PLEKHF1-low versus PLEKHF1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHF1→partner) and Y-score (partner→PLEKHF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC02662 →	+0.075	+5.103	<.001	.008	3	3
COAD	OR2T5 →	+0.209	+7.741	<.001	.009	3	2
COAD	RNU6-1139P →	+0.401	+7.741	<.001	.009	3	2
SKCM	KRT18P51 →	+0.264	+4.595	<.001	.004	3	2
STAD	RNU6-409P →	+0.823	+4.342	<.001	.002	3	2
STAD	NDUFA5P5 →	+0.238	+3.853	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 879 associations by consensus.

LINC02662 by PLEKHF1 expression — CESC

Explore this box plot interactively →