PLEKHF1

Across TCGA patient cohorts, PLEKHF1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHF1-associated genes across cancer lineages are Ku80, MSH6, and N-Ras. Each is linked with PLEKHF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHF1-to-partner and partner-to-PLEKHF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by PLEKHF1-low versus PLEKHF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHF1→partner) and Y-score (partner→PLEKHF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.292	+2.713	.006	.003	3	1
UCEC	MSH6 →	-0.369	-2.999	.013	.035	3	1
UCEC	N-Ras →	-0.121	-2.687	.024	.006	3	1
UCEC	p62 Lck ligand →	+0.330	+2.700	.024	.006	3	1
UCEC	p70-S6K →	+0.212	+2.026	.014	.018	3	1
UCEC	PDK1_pS241 →	+0.166	+2.321	.031	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Ku80 by PLEKHF1 expression — UCEC

Explore this box plot interactively →