PLEKHF1

Across TCGA cell cohorts, PLEKHF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,792 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PLEKHF1-associated GO terms across cancer lineages are Maintenance of protein localization in organelle, Negative regulation of immune response, and Negative regulation of response to biotic stimulus. Each is linked with PLEKHF1 in more than 12 cancer types. Because this analysis shows association rather than direction, both PLEKHF1-to-partner and partner-to-PLEKHF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maintenance of protein localization in organelle grouped by PLEKHF1-low versus PLEKHF1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHF1→partner) and Y-score (partner→PLEKHF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Maintenance of protein localization in organelle →	+0.162	+2.434	<.001	<.001	3	13
SOFT_TISSUE	Negative regulation of immune response →	+0.102	+1.661	<.001	<.001	3	12
SOFT_TISSUE	Negative regulation of response to biotic stimulus →	+0.086	+1.026	<.001	.002	3	12
BONE	Wound healing →	+0.129	+1.566	<.001	<.001	3	12
LIVER	Regulation of mitochondrial membrane potential →	+0.170	+1.171	<.001	.001	3	11
BONE	Protein targeting to vacuole involved in autophagy →	+0.192	+1.886	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,792 associations by consensus.

Maintenance of protein localization in organelle by PLEKHF1 expression — BONE

Explore this box plot interactively →