PLEKHD1

Across TCGA patient cohorts, PLEKHD1 mutation is significantly associated with the RNA expression of many other genes, with 1,688 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHD1-associated genes across cancer lineages are MIR4533, RNA5SP516, and TRAJ47. Each is linked with PLEKHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHD1-to-partner and partner-to-PLEKHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4533 grouped by PLEKHD1-low versus PLEKHD1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHD1→partner) and Y-score (partner→PLEKHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR4533 →	+0.222	+4.580	<.001	.004	3	2
UCEC	RNA5SP516 →	+0.180	+2.937	.001	.002	3	2
LIHC	TRAJ47 →	+0.346	+4.157	<.001	.008	3	2
LIHC	KCNJ6-AS1 →	+0.153	+3.652	.002	.002	3	2
CESC	LNCNEF →	+0.038	+4.384	<.001	.008	3	2
COAD	RN7SL83P →	+0.443	+4.807	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,688 associations by consensus.

MIR4533 by PLEKHD1 expression — LIHC

Explore this box plot interactively →