PLEKHB2

Across TCGA cell cohorts, PLEKHB2 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHB2-associated genes across cancer lineages are SIN3A, OTP, and OR4F21. Each is linked with PLEKHB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHB2-to-partner and partner-to-PLEKHB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIN3A grouped by PLEKHB2-low versus PLEKHB2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHB2→partner) and Y-score (partner→PLEKHB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SIN3A →	+0.690	+3.082	.009	.007	3	1
LARGE_INTESTINE	OTP →	+0.065	+3.295	<.001	.006	3	1
LARGE_INTESTINE	OR4F21 →	+0.103	+2.556	.001	.006	3	1
LARGE_INTESTINE	SH3BGR →	+0.872	+3.215	<.001	.009	3	1
LARGE_INTESTINE	CHSY3 →	+0.498	+3.302	<.001	.008	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.040	+2.672	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

SIN3A by PLEKHB2 expression — LARGE_INTESTINE

Explore this box plot interactively →