PLEKHB1

Across TCGA patient cohorts, PLEKHB1 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,260 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLEKHB1-associated proteins across cancer lineages are PPP1R9A_S840, WNK2, and PICK1. Each is linked with PLEKHB1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PLEKHB1-to-partner and partner-to-PLEKHB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHB1 versus PPP1R9A_S840 in HNSC, with a Pearson correlation of 0.67.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHB1→partner) and Y-score (partner→PLEKHB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PPP1R9A_S840 →	+1.490	+0.934	<.001	<.001	3	6
GBM	WNK2 →	+0.481	+0.820	<.001	<.001	3	5
HNSC	PICK1 →	+0.521	+1.220	<.001	.001	3	5
BRCA	TRIM2 →	+0.531	+1.298	.003	.003	3	5
GBM	STK39_T354 →	+0.748	+1.189	<.001	<.001	3	5
LSCC	MYEF2 →	+0.822	+0.793	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,260 associations by consensus.

PLEKHB1 vs PPP1R9A_S840 — HNSC

Explore this scatter interactively →