PLEKHB1

Across TCGA pan-cancer cohorts, PLEKHB1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PLEKHB1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PLEKHB1 RNA is repressed in tumor relative to normal tissue. In most cancer types PLEKHB1 is over-expressed in tumor, although a few such as KIRC and LUSC show the opposite, repressed pattern.

KIRC, LUSC, and LUAD are the cancer types where PLEKHB1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLEKHB1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−2.405	<.001	11	view →
LUSC	All	III,IV	−2.566	<.001	9	view →
LUAD	Female	III,IV	−1.165	<.001	9	view →
KIRP	Male	III,IV	−1.930	<.001	8	view →
THCA	Male	III,IV	−1.267	<.001	8	view →
UCEC	All	All	+1.547	<.001	6	view →
CHOL	Female	All	+4.540	<.001	5	view →
COAD	Female	II,III,IV	+1.580	<.001	5	view →
HNSC	All	All	−0.983	.001	5	view →
BRCA	Female	II,III,IV	−0.476	.018	4	view →
BLCA	Male	III,IV	−1.698	<.001	3	view →
KICH	Male	All	−1.548	.017	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PLEKHB1–KIRC

Open the KIRC breakdown →