PLEKHB1

Across TCGA patient cohorts, PLEKHB1 protein abundance is significantly associated with the RNA expression of many other genes, with 5,019 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLEKHB1-associated genes across cancer lineages are MCM5, DGKH, and RND3. Each is linked with PLEKHB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHB1-to-partner and partner-to-PLEKHB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHB1 versus MCM5 in GBM, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHB1→partner) and Y-score (partner→PLEKHB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MCM5 →	-0.569	-0.706	<.001	<.001	3	2
BRCA	DGKH →	-1.017	-0.558	.005	.004	3	2
GBM	RND3 →	-0.902	-0.521	<.001	.002	3	2
BRCA	DAGLA →	+1.012	+0.766	.009	.007	3	2
UCEC	NAB1 →	-0.615	-0.392	<.001	.007	3	2
GBM	ADAM21 →	-0.631	-0.605	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,019 associations by consensus.

PLEKHB1 vs MCM5 — GBM

Explore this scatter interactively →