PLEKHB1

Across TCGA patient cohorts, PLEKHB1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHB1-associated genes across cancer lineages are eEF2, EGFR_pY1068, and A-Raf_pS299. Each is linked with PLEKHB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHB1-to-partner and partner-to-PLEKHB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PLEKHB1-low versus PLEKHB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHB1→partner) and Y-score (partner→PLEKHB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.559	+3.000	<.001	.001	3	1
UCEC	EGFR_pY1068 →	-0.354	-3.807	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.195	-3.459	<.001	.005	3	1
UCEC	ERK2 →	+0.243	+2.584	.002	.010	3	1
UCEC	FoxM1 →	+0.254	+1.807	.017	.027	3	1
UCEC	FOXO3a_pS318_S321 →	-0.132	-1.990	.010	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

eEF2 by PLEKHB1 expression — UCEC

Explore this box plot interactively →