PLEKHB1

Across TCGA cell cohorts, PLEKHB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,292 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLEKHB1-associated GO terms across cancer lineages are Regulation of cytosolic calcium ion concentration, Hepatocyte apoptotic process, and Protein localization to cytoplasmic stress granule. Each is linked with PLEKHB1 in more than 8 cancer types. Because this analysis shows association rather than direction, both PLEKHB1-to-partner and partner-to-PLEKHB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cytosolic calcium ion concentration grouped by PLEKHB1-low versus PLEKHB1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHB1→partner) and Y-score (partner→PLEKHB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of cytosolic calcium ion concentration →	-0.118	-1.948	<.001	<.001	3	9
LUNG_SCLC	Hepatocyte apoptotic process →	+0.143	+2.882	.002	<.001	3	8
BREAST	Protein localization to cytoplasmic stress granule →	+0.088	+1.148	.001	.003	2	9
SKIN	Negative regulation of nucleotide biosynthetic process →	+0.157	+2.205	<.001	.002	3	8
SKIN	Negative regulation of purine nucleotide biosynthetic process →	+0.157	+2.205	<.001	.002	3	8
LUNG_NSCLC_LUAD	Regulation of smooth muscle cell chemotaxis →	+0.254	+1.525	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,292 associations by consensus.

Regulation of cytosolic calcium ion concentration by PLEKHB1 expression — OVARY

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