PLEKHB1

Across TCGA cell cohorts, PLEKHB1 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PLEKHB1-associated genes across cancer lineages are IFNA8 and OR11H6. Each is linked with PLEKHB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHB1-to-partner and partner-to-PLEKHB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA8 grouped by PLEKHB1-low versus PLEKHB1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHB1→partner) and Y-score (partner→PLEKHB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IFNA8 →	+0.035	+4.977	<.001	.007	3	1
SKIN	OR11H6 →	+0.022	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

IFNA8 by PLEKHB1 expression — SKIN

Explore this box plot interactively →