PLEKHA8

Across TCGA patient cohorts, PLEKHA8 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHA8-associated genes across cancer lineages are PKC-b-II_pS660, Di-Ras3, and FOXO3a_pS318_S321. Each is linked with PLEKHA8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHA8-to-partner and partner-to-PLEKHA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by PLEKHA8-low versus PLEKHA8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA8→partner) and Y-score (partner→PLEKHA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-b-II_pS660 →	-0.280	-2.000	.024	.032	3	2
UCEC	Di-Ras3 →	-0.143	-2.000	.032	.032	3	2
UCEC	FOXO3a_pS318_S321 →	-0.126	-2.700	.025	.006	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.630	+2.331	.005	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.253	-2.321	<.001	.033	3	1
UCEC	Ku80 →	+0.266	+2.013	.012	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

PKC-b-II_pS660 by PLEKHA8 expression — UCEC

Explore this box plot interactively →