PLEKHA8

Across TCGA cell cohorts, PLEKHA8 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLEKHA8-associated genes across cancer lineages are OR13C2, SIGLEC5, and DIPK2B. Each is linked with PLEKHA8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHA8-to-partner and partner-to-PLEKHA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13C2 grouped by PLEKHA8-low versus PLEKHA8-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA8→partner) and Y-score (partner→PLEKHA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR13C2 →	+0.012	+5.000	<.001	.006	3	1
LUNG_SCLC	SIGLEC5 →	+0.051	+3.817	<.001	.004	3	1
LUNG_SCLC	DIPK2B →	+0.015	+3.736	<.001	.007	3	1
LUNG_SCLC	CPXCR1 →	+0.034	+4.070	<.001	.003	3	1
LUNG_SCLC	DCD →	+0.868	+4.058	.001	.007	3	1
LUNG_SCLC	KRTAP4-6 →	+0.042	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

OR13C2 by PLEKHA8 expression — PANCREAS

Explore this box plot interactively →