PLEKHA8

Across TCGA cell cohorts, PLEKHA8 mutation is significantly associated with the mutation status of many other genes, with 849 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHA8-associated genes across cancer lineages are EXOC7, TRIM46, and PRRT2. Each is linked with PLEKHA8 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLEKHA8-to-partner and partner-to-PLEKHA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EXOC7 grouped by PLEKHA8-low versus PLEKHA8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA8→partner) and Y-score (partner→PLEKHA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EXOC7 →	+3.548	+3.845	.003	.003	1	4
BLOOD_Leukemia	TRIM46 →	+2.870	+3.347	.009	.009	1	3
BLOOD_Leukemia	PRRT2 →	+4.870	+4.560	<.001	<.001	1	3
LUNG_SCLC	NBPF14 →	+2.400	+4.025	.004	.004	1	3
LARGE_INTESTINE	CCDC33 →	+3.222	+2.893	.003	.003	1	3
LARGE_INTESTINE	FEM1A →	+3.222	+2.893	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 849 associations by consensus.

EXOC7 by PLEKHA8 expression — BLOOD_Leukemia

Explore this box plot interactively →