PLEKHA7

Across TCGA patient cohorts, PLEKHA7 mutation is significantly associated with the RNA expression of many other genes, with 5,349 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHA7-associated genes across cancer lineages are NOL12, RNU7-14P, and TAF13. Each is linked with PLEKHA7 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHA7-to-partner and partner-to-PLEKHA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOL12 grouped by PLEKHA7-low versus PLEKHA7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA7→partner) and Y-score (partner→PLEKHA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NOL12 →	+0.299	+1.572	<.001	<.001	3	3
CESC	RNU7-14P →	+0.564	+4.760	<.001	.003	3	3
UCEC	TAF13 →	+0.596	+1.722	<.001	<.001	3	3
UCEC	PRC1 →	+0.680	+1.917	<.001	<.001	3	3
UCEC	WDR76 →	+0.794	+2.384	<.001	<.001	3	3
SKCM	TSPY26P →	-0.659	-1.788	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,349 associations by consensus.

NOL12 by PLEKHA7 expression — UCEC

Explore this box plot interactively →