PLEKHA7

Across TCGA pan-cancer cohorts, PLEKHA7 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PLEKHA7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PLEKHA7 RNA is repressed in tumor relative to normal tissue. In most cancer types PLEKHA7 is over-expressed in tumor, although a few such as HNSC and KIRP show the opposite, repressed pattern.

HNSC, KIRP, and KICH are the cancer types where PLEKHA7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLEKHA7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	−1.027	<.001	11	view →
KIRP	All	III,IV	−1.080	.001	8	view →
KICH	All	All	−0.877	<.001	7	view →
BLCA	Male	All	+1.335	.021	6	view →
KIRC	Male	All	−0.636	<.001	6	view →
COAD	Female	II,III,IV	−0.964	<.001	5	view →
THCA	All	All	−0.460	.002	4	view →
BRCA	Female	II,III,IV	−0.324	.001	4	view →
CHOL	All	All	+1.311	.001	3	view →
LIHC	All	All	+0.405	.008	2	view →
PRAD	All	All	+0.315	.021	2	view →
LUAD	All	All	+0.256	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PLEKHA7–HNSC

Open the HNSC breakdown →