PLEKHA7

Across TCGA patient cohorts, PLEKHA7 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHA7-associated genes across cancer lineages are eEF2, TFRC, and c-Kit. Each is linked with PLEKHA7 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHA7-to-partner and partner-to-PLEKHA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PLEKHA7-low versus PLEKHA7-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA7→partner) and Y-score (partner→PLEKHA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eEF2 →	+0.396	+2.178	.004	.035	3	3
UCEC	TFRC →	+0.610	+2.050	<.001	<.001	3	3
UCEC	c-Kit →	-0.162	-1.184	.019	.022	3	3
UCEC	eIF4E →	+0.185	+1.999	.003	.002	3	2
UCEC	FASN →	+0.285	+1.378	.015	.008	3	2
UCEC	GAPDH →	+0.568	+1.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

eEF2 by PLEKHA7 expression — COAD

Explore this box plot interactively →