PLEKHA7

Across TCGA cell cohorts, PLEKHA7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,554 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PLEKHA7-associated GO terms across cancer lineages are Negative regulation of Arp2/3 complex-mediated actin nucleation, Response to indole-3-methanol, and Phospholipid biosynthetic process. Each is linked with PLEKHA7 in more than 10 cancer types. Because this analysis shows association rather than direction, both PLEKHA7-to-partner and partner-to-PLEKHA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of Arp2/3 complex-mediated actin nucleation grouped by PLEKHA7-low versus PLEKHA7-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA7→partner) and Y-score (partner→PLEKHA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.317	+2.771	<.001	<.001	3	11
STOMACH	Response to indole-3-methanol →	+0.227	+2.451	<.001	<.001	3	11
URINARY_TRACT	Phospholipid biosynthetic process →	+0.041	+1.821	.002	.009	3	11
STOMACH	Action potential propagation →	-1.289	-2.590	<.001	<.001	3	11
URINARY_TRACT	Negative regulation of cytoskeleton organization →	+0.079	+3.033	<.001	<.001	3	10
PANCREAS	Micturition →	-0.999	-1.750	.003	.005	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,554 associations by consensus.

Negative regulation of Arp2/3 complex-mediated actin nucleation by PLEKHA7 expression — LIVER

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