PLEKHA7

Across TCGA cell cohorts, PLEKHA7 mutation is significantly associated with the RNA expression of many other genes, with 327 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHA7-associated genes across cancer lineages are OR5AU1, NABP2, and LRIT1. Each is linked with PLEKHA7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHA7-to-partner and partner-to-PLEKHA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5AU1 grouped by PLEKHA7-low versus PLEKHA7-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA7→partner) and Y-score (partner→PLEKHA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR5AU1 →	+0.015	+3.342	<.001	.008	3	2
LARGE_INTESTINE	NABP2 →	+0.470	+2.537	.002	.008	3	2
LARGE_INTESTINE	LRIT1 →	+0.015	+2.157	.004	.005	3	2
LARGE_INTESTINE	NAE1 →	+0.743	+3.588	<.001	<.001	3	2
LARGE_INTESTINE	SENP3 →	+0.510	+3.067	.003	.009	3	2
BLOOD_Leukemia	NKX2-6 →	+0.224	+3.201	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 327 associations by consensus.

OR5AU1 by PLEKHA7 expression — BLOOD_Lymphoma

Explore this box plot interactively →