PLEKHA6

Across TCGA patient cohorts, PLEKHA6 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHA6-associated genes across cancer lineages are PKC-a_pS657, eIF4G, and Caspase-7-cleavedD198. Each is linked with PLEKHA6 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHA6-to-partner and partner-to-PLEKHA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-a_pS657 grouped by PLEKHA6-low versus PLEKHA6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA6→partner) and Y-score (partner→PLEKHA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PKC-a_pS657 →	+0.369	+2.000	.033	.031	3	3
UCEC	eIF4G →	+0.220	+1.058	.015	.037	3	3
BLCA	Caspase-7-cleavedD198 →	+0.792	+3.000	.013	.036	3	2
UCEC	p53 →	-0.233	-1.874	.041	.049	3	2
UCEC	Annexin-1 →	+0.430	+1.300	.005	.034	3	2
UCEC	S6_pS240_S244 →	+0.276	+1.241	.020	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

PKC-a_pS657 by PLEKHA6 expression — SKCM

Explore this box plot interactively →