PLEKHA6

Across TCGA pan-cancer cohorts, PLEKHA6 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PLEKHA6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PLEKHA6 RNA is repressed in tumor relative to normal tissue. In most cancer types PLEKHA6 is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

KICH, HNSC, and KIRC are the cancer types where PLEKHA6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLEKHA6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	IV	−2.237	<.001	11	view →
HNSC	Male	IV	−1.814	<.001	10	view →
KIRC	Male	II,III,IV	−0.965	<.001	9	view →
LUAD	Male	II,III,IV	+1.936	<.001	8	view →
STAD	Male	All	+1.057	<.001	6	view →
COAD	Female	All	−0.552	.001	4	view →
BRCA	All	All	+0.378	.007	4	view →
CHOL	All	All	+1.701	<.001	3	view →
PAAD	All	All	+1.764	.008	2	view →
LIHC	Male	All	+0.787	<.001	2	view →
LUSC	All	All	−0.509	.024	2	view →
PRAD	All	All	−0.292	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PLEKHA6–KICH

Open the KICH breakdown →