PLEKHA6

Across TCGA cell cohorts, PLEKHA6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,507 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHA6-associated GO terms across cancer lineages are Negative regulation of supramolecular fiber organization, Regulation of potassium ion import, and Regulation of postsynaptic membrane neurotransmitter receptor levels. Each is linked with PLEKHA6 in more than 10 cancer types. Because this analysis shows association rather than direction, both PLEKHA6-to-partner and partner-to-PLEKHA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of supramolecular fiber organization grouped by PLEKHA6-low versus PLEKHA6-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA6→partner) and Y-score (partner→PLEKHA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of supramolecular fiber organization →	+0.076	+1.819	<.001	.001	3	11
OVARY	Regulation of potassium ion import →	+0.196	+1.658	<.001	.002	3	10
OESOPHAGUS	Regulation of postsynaptic membrane neurotransmitter receptor levels →	+0.110	+2.277	<.001	<.001	3	10
STOMACH	Response to progesterone →	+0.164	+2.139	.001	<.001	3	10
LUNG_SCLC	Anterograde dendritic transport →	+0.213	+2.879	<.001	<.001	3	10
OESOPHAGUS	Regulation of cellular component size →	+0.057	+2.579	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,507 associations by consensus.

Negative regulation of supramolecular fiber organization by PLEKHA6 expression — OVARY

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