PLEKHA6

Across TCGA cell cohorts, PLEKHA6 mutation is significantly associated with the RNA expression of many other genes, with 1,167 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHA6-associated genes across cancer lineages are NUMBL, GPR63, and C12orf29. Each is linked with PLEKHA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHA6-to-partner and partner-to-PLEKHA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUMBL grouped by PLEKHA6-low versus PLEKHA6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA6→partner) and Y-score (partner→PLEKHA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NUMBL →	+0.632	+2.584	.005	.005	3	2
BLOOD_Leukemia	GPR63 →	+0.929	+3.437	<.001	.001	3	2
BLOOD_Leukemia	C12orf29 →	+0.671	+3.290	<.001	.003	3	2
LARGE_INTESTINE	BTF3L4 →	+0.565	+2.115	.002	.004	3	2
BLOOD_Leukemia	TOM1L1 →	+1.410	+3.115	.001	.009	3	2
LARGE_INTESTINE	SKA1 →	+0.768	+3.130	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,167 associations by consensus.

NUMBL by PLEKHA6 expression — BLOOD_Leukemia

Explore this box plot interactively →