PLEKHA5

Across TCGA patient cohorts, PLEKHA5 mutation is significantly associated with the RNA expression of many other genes, with 4,440 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHA5-associated genes across cancer lineages are CAMTA1-AS2, RNU6-189P, and PTP4A3. Each is linked with PLEKHA5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHA5-to-partner and partner-to-PLEKHA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CAMTA1-AS2 grouped by PLEKHA5-low versus PLEKHA5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA5→partner) and Y-score (partner→PLEKHA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CAMTA1-AS2 →	+0.067	+3.010	<.001	.003	3	3
SKCM	RNU6-189P →	+0.208	+3.665	<.001	.002	3	3
UCEC	PTP4A3 →	-0.664	-3.989	<.001	<.001	3	3
UCEC	RNU6-42P →	+0.433	+1.478	.003	.008	3	3
UCEC	AOC1 →	-2.006	-2.485	<.001	<.001	3	3
LIHC	MIR6076 →	+0.298	+3.138	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,440 associations by consensus.

CAMTA1-AS2 by PLEKHA5 expression — SKCM

Explore this box plot interactively →