PLEKHA4

Across TCGA cell cohorts, PLEKHA4 mutation is significantly associated with the RNA expression of many other genes, with 168 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLEKHA4-associated genes across cancer lineages are CRYBB1, SEL1L2, and FGF3. Each is linked with PLEKHA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHA4-to-partner and partner-to-PLEKHA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYBB1 grouped by PLEKHA4-low versus PLEKHA4-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA4→partner) and Y-score (partner→PLEKHA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CRYBB1 →	+0.026	+4.906	<.001	.006	3	1
URINARY_TRACT	SEL1L2 →	+0.030	+5.087	<.001	.004	3	1
CNS	FGF3 →	+0.043	+4.981	<.001	.008	3	1
CNS	FAM205C →	+0.047	+4.981	<.001	.008	3	1
LARGE_INTESTINE	DCTN6 →	+0.556	+3.212	.009	.006	3	1
LARGE_INTESTINE	RSPH6A →	+0.098	+3.129	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 168 associations by consensus.

CRYBB1 by PLEKHA4 expression — OESOPHAGUS

Explore this box plot interactively →