PLEKHA3

Across TCGA patient cohorts, PLEKHA3 protein abundance is significantly associated with the RNA expression of many other genes, with 4,017 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PLEKHA3-associated genes across cancer lineages are LINC01550, C3orf52, and KCNMB4. Each is linked with PLEKHA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEKHA3-to-partner and partner-to-PLEKHA3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEKHA3 versus LINC01550 in GBM, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA3→partner) and Y-score (partner→PLEKHA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LINC01550 →	-0.881	-0.335	<.001	.001	3	3
BRCA	C3orf52 →	+0.646	+0.211	.003	<.001	3	2
LSCC	KCNMB4 →	+0.926	+0.204	<.001	.003	3	2
BRCA	SLC7A13 →	+0.553	+0.234	.002	<.001	3	2
OV	REEP3 →	+0.749	+0.940	.002	.003	3	2
LSCC	RASSF6 →	+0.892	+0.196	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,017 associations by consensus.

PLEKHA3 vs LINC01550 — GBM

Explore this scatter interactively →