PLEKHA1

Across TCGA patient cohorts, PLEKHA1 mutation is significantly associated with the RNA expression of many other genes, with 2,894 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEKHA1-associated genes across cancer lineages are USP9YP10, OR12D1, and RPL22P14. Each is linked with PLEKHA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEKHA1-to-partner and partner-to-PLEKHA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP9YP10 grouped by PLEKHA1-low versus PLEKHA1-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEKHA1→partner) and Y-score (partner→PLEKHA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2
READ	OR12D1 →	+0.108	+6.257	<.001	.001	3	2
LIHC	RPL22P14 →	+0.125	+5.544	<.001	.004	3	2
UCEC	IGHD1-26 →	+0.388	+2.221	<.001	.005	3	2
UCEC	RNA5SP415 →	+0.361	+1.836	.001	.005	3	2
LUSC	FABP5P15 →	+0.202	+5.151	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,894 associations by consensus.

USP9YP10 by PLEKHA1 expression — LGG

Explore this box plot interactively →