PLEK

Across TCGA pan-cancer cohorts, PLEK mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PLEK data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PLEK mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PLEK expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

COAD, PDAC, and HNSC are the cancer types where PLEK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	II,III,IV	0.800	1.000	.009	114	view →
PDAC	OS	Quartile	II,III,IV	0.536	0.995	.002	13	view →
HNSC	OS	Median	III,IV	1.000	0.946	.037	9	view →
CCRCC	DFS	Quartile	All	0.862	1.000	.014	7	view →
GBM	OS	Quartile	All	0.380	0.628	.045	4	view →
LUAD	DFS	Median	All	0.736	0.540	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PLEK–COAD (DFS)

Open the COAD breakdown →