PLEK

Across TCGA pan-cancer cohorts, PLEK RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PLEK’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PLEK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PLEK is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, KIRP, and STAD are the cancer types where PLEK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLEK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.557	<.001	12	view →
KIRP	Male	III,IV	+1.891	<.001	9	view →
STAD	All	All	+1.287	<.001	7	view →
LUAD	All	II,III,IV	−0.875	<.001	7	view →
LUSC	All	All	−1.241	<.001	6	view →
BRCA	Female	All	+0.369	.008	4	view →
THCA	Male	IV	+2.030	.015	1	view →
ESCA	All	All	+1.226	.041	1	view →
KICH	All	II,III,IV	−0.729	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

PLEK–KIRC

Open the KIRC breakdown →