PLEK

Across TCGA patient cohorts, PLEK protein abundance is significantly associated with the RNA expression of many other genes, with 20,317 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PLEK-associated genes across cancer lineages are IL2RB, TLR8, and TNFSF13B. Each is linked with PLEK in more than 9 cancer types. Because this analysis shows association rather than direction, both PLEK-to-partner and partner-to-PLEK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLEK versus IL2RB in HNSC, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEK→partner) and Y-score (partner→PLEK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IL2RB →	+1.210	+0.684	<.001	<.001	3	10
GBM	TLR8 →	+1.012	+0.521	<.001	<.001	3	10
OV	TNFSF13B →	+1.029	+0.477	<.001	<.001	3	10
HNSC	IL21R →	+0.896	+0.504	.001	<.001	3	10
UCEC	LILRB1 →	+0.959	+0.642	<.001	<.001	3	10
HNSC	RASAL3 →	+1.180	+0.601	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,317 associations by consensus.

PLEK vs IL2RB — HNSC

Explore this scatter interactively →