PLEK

Across TCGA patient cohorts, PLEK mutation is significantly associated with the RNA expression of many other genes, with 2,727 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEK-associated genes across cancer lineages are GHITM, COX5A, and TOMM22P5. Each is linked with PLEK in more than 2 cancer types. Because this analysis shows association rather than direction, both PLEK-to-partner and partner-to-PLEK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHITM grouped by PLEK-low versus PLEK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEK→partner) and Y-score (partner→PLEK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GHITM →	+0.462	+2.807	.008	<.001	3	3
SKCM	COX5A →	+0.341	+2.434	.001	.001	3	3
SKCM	TOMM22P5 →	+0.112	+1.797	<.001	.002	3	3
UCEC	SAMM50 →	+0.474	+2.828	.001	<.001	3	3
UCEC	MRPL37 →	+0.596	+2.807	<.001	<.001	3	3
SKCM	GOT1 →	+0.401	+3.738	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,727 associations by consensus.

GHITM by PLEK expression — UCEC

Explore this box plot interactively →