PLEK

Across TCGA patient cohorts, PLEK mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLEK-associated genes across cancer lineages are Cyclin-B1, eEF2, and EGFR_pY1068. Each is linked with PLEK in more than 1 cancer types. Because this analysis shows association rather than direction, both PLEK-to-partner and partner-to-PLEK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by PLEK-low versus PLEK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEK→partner) and Y-score (partner→PLEK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.565	+2.000	.008	.029	3	2
UCEC	eEF2 →	+0.420	+3.169	.002	.018	3	1
UCEC	EGFR_pY1068 →	-0.363	-4.321	<.001	<.001	3	1
UCEC	ERK2 →	+0.178	+1.678	.016	.023	3	1
UCEC	GATA6 →	-0.149	-2.459	.016	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.196	-2.807	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Cyclin-B1 by PLEK expression — UCEC

Explore this box plot interactively →