PLEK

Across TCGA cell cohorts, PLEK RNA expression is significantly associated with the go_rna of many other GO terms, with 3,575 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PLEK-associated GO terms across cancer lineages are Neutrophil-mediated killing of fungus, Viral translational termination-reinitiation, and Negative regulation of myoblast fusion. Each is linked with PLEK in more than 7 cancer types. Because this analysis shows association rather than direction, both PLEK-to-partner and partner-to-PLEK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neutrophil-mediated killing of fungus grouped by PLEK-low versus PLEK-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLEK→partner) and Y-score (partner→PLEK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Neutrophil-mediated killing of fungus →	+1.085	+2.218	<.001	.001	3	8
UPPER_AERODIGESTIVE_TRACT	Viral translational termination-reinitiation →	+0.100	+0.073	.001	.002	3	7
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.085	+0.067	.006	.003	3	7
PANCREAS	Cytoplasmic translation →	+0.054	+0.049	<.001	.004	3	7
LARGE_INTESTINE	Negative regulation of syncytium formation by plasma membrane fusion →	+0.076	+0.160	<.001	<.001	3	7
CNS	Regulation of RNA polymerase II transcription preinitiation complex assembly →	+0.128	+0.213	<.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,575 associations by consensus.

Neutrophil-mediated killing of fungus by PLEK expression — BLOOD_Leukemia

Explore this box plot interactively →